We introduce a resource comprising curated results of retrograde tracer injections performed in the cortex of marmosets ( Callithrix jacchus), made accessible through a web site ( ).
This resource helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-based analyses of human brains.
It also provides purely spatial (parcellation-free) data, based on the stereotaxic coordinates of 2 million labeled neurons. The resource incorporates tools for analyses relative to cytoarchitectural areas, including statistical properties such as the fraction of labeled neurons and the percentage of supragranular neurons. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by expert delineation of histological borders, allowing accurate assignment of connections to areas despite interindividual variability. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets.
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